BACKGROUND: The role of serum uric acid and creatinine in the pathogenesis of preeclampsia has been consistently debated. Different researchers have found controversial results with regards to serum levels of uric acid and creatinine in pregnancies complicated by preeclampsia. OBJECTIVE: To compare the mean serum concentration of uric acid and creatinine in pre-eclamptic and nomotensive women in Enugu. DESIGN: This was a case-control analytical study of pregnant women with preeclampsia and normotensive receiving antenatal care at the University of Nigeria Teaching Hospital (UNTH) and Mother of Christ Specialist Hospital (MOCSH), Enugu. There were also some who were recruited as unbooked cases but who were qualified for the study. This research was conducted at the antenatal clinic, and the antenatal/labour wards of the two hospitals. PATIENTS: A total of one hundred and thirty two eligible women were recruited for the studies. They were sixty six participants in each of the two arms of the study group. The cases (Group A) were eligible consecutive pregnant women diagnosed with pre-eclampsia at third trimester (28-40 weeks). The controls (Group B) were made up of consecutive eligible normotensive women selected on 1:1 ratio and matched with the cases for age, parity and gestational age. MAIN OUTCOME MEASURES: The primary outcome measures included the mean serum concentration of uric acid and creatinine in both groups. DATA ANALYSIS All data collected from the study were recorded on ‘case record forms’ prepared for the study. Thereafter, they were keyed into the statistical package for social sciences (SPSS) computer software version 20.0 for windows. All tests were two-sided and the statistical significance was considered to be at probability value of < 0.05.