AIM; To identify ocular features seen in children presenting with malaria in University of Benin Teaching Hospital (UBTH), Benin City, with a view to establishing a predictive and prognostic value and to determine if there is any diagnostic usefulness of ocular features seen in children with malaria in UBTH. MATERIALS AND METHODS In this hospital-based case control study at the UBTH, subjects and controls who satisfied the inclusion criteria of the study, underwent ophthalmic examination for ocular features of malaria and were assessed for relevant laboratory indices necessary in the diagnosis of malaria using the revised 2014 WHO criteria. A structured questionnaire, which was interviewer- administered was used to record data. Data were analyzed using the Statistical Software Package SPSS, version 21. Quantitative variables were summarized using descriptive statistics. Relationship between ocular features and the identified factors were presented as bivariate frequency tables and charts where applicable. The association between ocular features seen and the clinical syndromes of malaria infection was analyzed using Chi- square tests and Logistic regression. The level of significance of each test was set at p < 0.05 and 95% confidence interval. RESULTS One hundred and seventy eight (178) children who had malaria were recruited into the study and 178 children who did not have malaria were included as controls after they were screened for plasmodium falciparum malaria parasite using the WHO standard laboratory diagnostic technique. Of the cases 102(57.3%) were males while 76(42.7%) were females. Males constituted 98(55.1%) while 80(44.9%) were females in the control group. The ages ranged from 11 months to 16 years for cases and 3 years to 17 years for control with a mean age of 4.08±3.85 and 4.04±2.49for the cases and control respectively[w1]. Both anterior segment features and posterior segment features of malaria were seen among cases in children with malaria. These included conjunctival pallor (12%) and icterus (5.6%) in the anterior segment. Posterior segment features included vessel abnormalities (19.1%), macular whitening (11.2%), retinal haemorrhage (7.8%), retinal whitening (7.8%), disc pallor (6.1%), papilloedema (5.6%) and macular haemorrhage (3.4%) in decreasing level of prevalence. Ocular features of malaria encountered were directly linked to the severity of malaria and were predictive of coma in these children. Children who had papilloedema were 7 times more likely to be comatose than those who did not have papilloedema (OR =7.13, p =0.027). Children who had vessel abnormalities (tortuous and engorged) were 6 times more likely to go into coma than those who did not have vessel abnormalities (OR = 5.71, p = 0.033), and those who had macular whitening were 6 times more likely to go into coma than those who did not have macular whitening (OR = 5.81, p = 0.021). Children who had retinal haemorrhage had 3 times the odds of having coma than children who did not have retinal haemorrhage. (OR= 2.748, p = 0.281)