The study design was an observational, cross sectional study of the “Correlation of renal
ultrasound findings with renal function in hypertensive patients with albuminuria”. The sample
size was one hundred and seventy patients for both the subjects and the controls, and they were
matched for; age, sex and BMI. Two hundred and three consecutive patients that met the
inclusion criteria were recruited for the study. One hundred and seventy three participants were
finally analyzed.
Hypertension was defined as blood pressure of 140/90 mmHg or greater on two consecutive occasions
or when the patient has been receiving antihypertensive drugs. A structured questionnaire which
documented the historical details of the hypertension was completed per eligible subject. The urinary
albumin was tested for, using albustix strips and was subsequently confirmed and quantified using
bromocresol green method, and the creatinine was determined using alkaline picric acid (Jaffe method).
Renal function was assessed using serum creatinine levels and the glomerular filtration rate (GFR) was
estimated by the Cockcroft and Gault formula. The ultrasound scanning of the kidney was done in the
radiology department of the University College Hospital, Ibadan by two sonologists. The renal
ultrasound was done, with the patient in prone and oblique positions for the left kidney and supine
position for the right kidney respectively, the liver was used as the window for the right kidney. The
probe used was 3.5MHz frequency Aloka. There are two sonologists at each scanning sessions, and the
two of them agreeing to the findings before it is recorded.
The subjects are the newly diagnosed hypertensives with albuminuria on albustix strip test while the
controls are the newly diagnosed hypertensives with no albuminuria in their urine.
Results: There was no association between the left renal length and diastolic blood pressure of the
subjects and the controls (r = 0.069, p = 0.342 and r = 0.093, p = 0.389) respectively, and also the SBP
for the subjects and the controls (r = -0.034, p = 0.798 and r = 0.125, p = 0.245). There was no
association between the SBP and GFR for both the subjects and the controls (r = 0.099, p = 0.483 and r =
-0.076, p =0.593).Also, no association between the DBP and the GFR for both the subjects and the
controls (r = -0.169 p= 0.116, r = 0.13 p = 0.908).
The analysis of variance between the echogenicity and GFR of the subjects and the controls were
significant (f = 26.14, p= 0.000). There was also, a significant negative association between the BMI and
the GFR of the subjects but not of the controls (r = -0.173, p = 0.032, and r = 0.049, p = 0.464)
respectively. There was a significant association between the albumin-creatinine ratio and the BMI (r =
0.218, p = 0.028). There was significant positive association between the GFR and the left renal length in
both the subjects and the controls (r = 0.334, p= 0.008, and r = 0.282, p= 0.009), but for the right renal
length and the GFR, there was positive association in the subjects but not in the controls (r = -0.331, p =
0.008 and r = 0.16, p = 0.331).
There was no correlation between the GFR and the albumin-creatinine ratio in the subjects (r = -0.047 p
= 0.156). Also, there was no correlation between the SBP and DBP and the albumin-creatinine ratio for
the subjects (r = -0.118 p = 0.508, r = 0.063 p = 0.644). There was no correlation between the renal
length and the albumin-creatinine ratio (r -0.018 p = 0.737, r = 0.04 p = 0.894) for the left and right
kidneys respectively. However, the analysis of variance between the albumin-creatinine ratio and
echogenicity was significant (f = 0.73, p = 0.023)
The mean BMI for the subjects was 27.9kg/m2 ± 6.3 SD and that of the controls was 28.6kg/m2 ± 7.5 SD.
There was no significant difference in it (p = 0.52).
The mean GFR for the subjects was 88.8mls/min ± 26.2 SD and 81.8mls/min ± 20.5 SD for the controls
and it was significant (p = 0.05)
The mean SBP for the subjects was 151.1mmHg ± 22.1 SD and for the controls was 151.0 ± 16.8. The
difference was not significant (p = 0.985)
The mean DBP for the subjects was 94.5mmHg ± 13.6 SD and for the controls was 94.4 ± 8.8 SD, the
difference was not significant (p = 0.95)
The mean renal length for the subjects was 10.3cm and standard deviation was 0.58, while the mean
renal length for the controls was 10.4cm and the standard deviation was 0.57. There was no difference
in the renal length between the subjects and the controls (p = 0.192).
Conclusions: There was an association between the GFR and renal echogenicity and also, between the
renal length and GFR for both the subjects and the controls. There was an association between the
albumin-creatinine ratio and echogenicity and also, between the albumin-creatinine ratio and the BMI.
There was also, an association between the BMI and the GFR of the subjects but not of the controls.
However there was no association between the GFR and the albumin-creatinine ratio and also, between
the albumin-creatinine ratio and the blood pressure measurements. There was no association between
the renal length and blood pressure for the subjects and the controls. There was significant difference
between the GFR of the subjects and the controls despite the fact that there was no significant
difference in their blood pressure measurements