This prospective study was undertaken to ascertain the incidence, frequency, histology and pathological features of different types of asymptomatic or sub clinical prostatic diseases. Prostate glands were obtained from 79 individuals who died from non-prostate related diseases at the University College Hospital Ibadan between February 3, 2010 and November 12, 2011. The glands were weighed and fixed in 10% neutral buffered formalin. The sampling method of the prostate gland described by Bostwick and Meiers (2009) was employed in this study. Paraffin embedded sections were stained with haematoxylin and eosin and were systematically examined for focal prostate disease. The patients’ ages ranged from 30 to 86 years. The most common lesions were nodular hyperplasia (81%), and adenocarcinoma (6.3%). Three cases (3.8%) had schistosomiasis. Adenocarcinoma and nodular hyperplasia occurred in relatively older patients than those with normal glands or chronic prostatitis/schistosomiasis (p = 0.05). There was an increase in the weight of prostate with age (p < 0.001) and normal prostate glands weighed significantly less than diseased glands (p = 0.02).Focal prostatic atrophy was observed in 24.1% and metaplastic changes were observed in eight (10.1%) of the cases. The low frequency of prostatic adenocarcinoma and the absence of high grade prostatic intraepithelial neoplasia in this study and a previous study from Lagos, Nigeria despite the observation of increasing 1 number of prostatic carcinoma require further investigation. Schistosomiasis was also found to be present in the adult male population.