OBJECTIVE: To study the receptors-status of Nigerian patients with Breast Cancer presenting at the Lagos University Teaching Hospital (LUTH) and evaluate any correlation with the disease state. PATIENTS AND METHODS: A descriptive longitudinal study of 230 patients with breast cancer was carried out. All had Tru-cut biopsy done. Indications for biopsy were: clinically diagnosed patients with breast cancers and patients with breast lumps at presentation. Clinical evaluations of all the patients were done, followed by radiological investigations before biopsy. Biopsy specimens were obtained, and fixed by author while pathologist reported the results. The receptor statuses of these specimens were determined and their correlations with the disease state determined. RESULTS: The receptors-statuses of the 203 patients (88.3%) who were eligible for analysis were determined, while 27 (11.7%) patients had their receptor-statuses undetermined. Age at presentation ranged from 20 – 80 years, with majority in the age group 41 – 50 years. The mean age was 45.1 years ± 12.2 years. Out of 203 patients whose data were analysed, 200 patients (98.5%) were females while 3 patients (1.5%) were males. Majority, 134 patients (67.0%) were premenopausal while 66 patients (33.0%) were menopausal. Out of 203 patients, 185 patients (91.1%) had invasive ductal carcinoma, 15 patients (7.4%) had invasive lobular carcinoma, while the remaining 3 patients (1.5%) were made up of other types. Most patients (91.1%) were stage 3 disease while 64.3% had short duration of symptoms between 4months – 12months Those with ER+, PR+, and HER-2+ were 46.3%, 29.1%, and 24.6% respectively while 37.4% were triple - negative. The rest 127 patients (62.6%) were positive for at least one of the receptors. Of the total number, 192 patients (94.6%) were lymph node positive, while 11 patients (5.4%) were lymph node negative. Majority of the tumours were of large sizes between 10x10cm and 14x14cm. Metastatic disease was established in 56.5% of the patients. There was also an established association between the receptor – statuses of the patients and disease complications at presentation. CONCLUSION: This study showed 46.3% prevalence of oestrogen positive receptor status and 37.4% prevalence of triple negative receptor status among patients with breast cancers seen at the Lagos University Teaching Hospital (LUTH), Lagos during the period of study. It also showed that majority of the patients were young, premenopausal and presented at advanced stage with substantial regional lymph nodes involvement, and had short duration of symptoms with large tumour sizes. The study also demonstrated an observable significant correlation of receptor-statuses with disease complications at presentation.