Adolescents with sickle cell anaemia (SCA) are challenged by a myriad of complex psychosocial issues, which may be triggered or exacerbated by stigmatisation. The magnitude of childhood stigma and its potential for associated psychosocial adjustment issues is scarcely being assessed, as more focus is often given to the physical symptoms and signs of SCA. This study, therefore, sought to assess the prevalence of perceived stigma, its associated factors and effects in adolescents with SCA in steady state, seen at the University of Port Harcourt Teaching Hospital (UPTH). Using a hospital-based, cross-sectional design, 200 adolescents with SCA (subjects) were recruited consecutively from July 2017 to March 2018 at the Paediatric Haematology Clinic of UPTH. Controls matched for age, gender, and socio-economic class, with haemoglobin genotype AA or AS were recruited from the Children Outpatient Clinic of UPTH. A self-administered questionnaire was used to obtain the clinico-demographic and psychosocial data. A validated perceived stigma scale was used in this study. The study participants were also examined for some clinical characteristics associated with SCA (jaundice, frontal bossing, gnathopathy and chronic leg ulcers). There were 97 (48.5%) males and 103 (51.5%) females in each group with a male to female ratio of 1: 1.1. Overall, perceived stigma was present in 159 (79.5%) subjects and 16 (8.0%) controls (p= 0.001). Subjects in early and mid-adolescence were about three times more likely to experience perceived stigma than those in late adolescence (OR= 2.9; 95% CI= 1.1-7.7; p= 0.031). Perceived stigma was significantly higher in subjects with three to four sickle cell pain crises and three or more hospital admissions in the preceding one year (p= 0.035 and 0.001 respectively). Perceived stigma was also significantly higher in subjects with a negative perception of their clinical characteristics (p= 0.001) and those who felt they were treated differently by peers and health workers (p= 0.001). One hundred and fifty-eight (79.0%) subjects had a depressive feeling, 122 (61.0%) avoided the health care system, 39 (19.5%) had social withdrawal and 17 (8.5%), suicidal ideation. Perceived Stigma was significantly associated with these four psychosocial effects (pvalue < 0.05).