The aim of this study was to evaluate non-infectious blood transfusion reactions occurring among individuals receiving health care at Obafemi Awolowo University Teaching Hospitals complex Ile-ife, with a view to determining the incidence of the various reactions and factors that may influence them. Over a period of 19 months, 258 blood transfusion recipients, who had not been transfused within two weeks prior to the admission, participated in the study. A questionnaire was prepared and tested in a pilot study of 10 patients for validity, and administered on recipients. Appropriate laboratory tests were carried out where indicated. Data was collated and analyzed using descriptive and inferential statistics. A p value <0.05 was significant. The results showed that 462 transfusions of blood and blood products were observed in 258 individuals who consisted of adults (60.9%) and children (39.1%). There were significantly more female adults than males (p=0.031) and more male children than female (p<0.05). The overall M:F ratio was however 1. for children. The commonest indication for transfusion of blood and blood products was moderate/severe anaemia (70.9%), surgical indications accounted for 16.7%, while others such as chemotherapy, haemodialysis and exchange transfusions accounted for 12.4% of all transfusions. Red cell transfusions comprised 71.8% of all blood components transfused and was mostly required by children (38.2%), followed by adults in medical wards (28.3%), Obstetrics and Gynaecology (19.3%) and surgical patients (14.2%). The overall incidence of adverse transfusion reactions was 8.7%. There was no significant difference in the incidence of BTR between adults and children. Individuals with previous history of transfusions had a significantly higher risk of an adverse event (p<0.05). Adult female recipients had an insignificant higher incidence of adverse transfusion event than males (15% to 11%). Incidence of BTR among SCA patients was lower than expected. Febrile non-haemolytic transfusion reaction constituted the highest burden occurring in 82.5% of those with adverse reactions. It was however sub-clinical in 23% of such reactions and would have gone unnoticed. 3.9% of all transfusions were discontinued (n=18). Of the transfusions discontinued, FNHTR constituted 66.7% but following intervention, only 2.2% of all transfusions were terminated (n=9). Immediate haemolytic transfusion reaction was not seen but delayed haemolytic transfusion reaction was observed in two patients (0.4%) and constituted 5% of transfusion reactions. The offending antigen in one patient could however not be determined. In conclusion, adverse transfusion reactions were not uncommon in the population studied and occurred in both adults and children alike. FNHTR was the commonest transfusion reaction observed, and was underreported having presented sub-clinically in some recipients. Ultimately with intervention, only half of cases of transfusion that were stopped due to transfusion reactions were terminated