Asthma is a heterogeneous disease with a rising prevalence in children and one of the leading causes of missed school days. It is characterised by chronic airway inflammation from oxidants such as reactive oxygen species and reactive nitrogen species. This chronic inflammation leads to airway smooth muscle reactivity, injury, and remodelling. Antioxidants are known to counteract the effects of these oxidants. Zinc is an essential trace element and co-factor to antioxidants such as catalase and superoxide dismutase which counteract the effects of these oxidants. The primary objective was to determine and compare the serum zinc levels of stable asthmatic children and non-asthmatic children. The secondary objectives were to determine if there exists any relationship between the serum zinc levels with asthma severity and socio-demographic characteristics of stable asthmatic children attending asthma clinic at Enugu State University of Science and Technology Teaching Hospital, Enugu. Methodology: A descriptive cross-sectional study was carried out on 170 children (85 subjects and 85 controls), aged five to 11 years. Both study groups were matched for age and sex. Biodata, socio-economic class, medical history, and anthropometric parameters were obtained using a structured questionnaire. Asthma severity for children with stable asthma was categorised using National Asthma Education and Prevention Program Expert Panel Report 3 guidelines. Serum zinc level was determined using Flame Atomic Absorption Spectrophotometer (FAAS).