Background: Pre-eclampsia is a cause of maternal and perinatal morbidities and mortality globally. Full understanding of aetiology of pre-eclampsia is still lacking despite large volumes of studies on this disease. Lipid profile derangement and oxidative stress have been suggested to have a possible aetiological link in pre-eclampsia, and may also contribute to morbidity and mortality. There are few studies available on lipid profile in pre-eclampsia and their association with maternal and perinatal outcomes and none in existent in our environment. Aims: To compare serum lipid profile among pre-eclamptics and normotensive pregnant women and their outcomes. Research Method: this study was a prospective cohort study at Federal Teaching Hospital, Abakaliki involving 112 pregnant women from April 2019 to October 2019. The participants were recruited at the antenatal clinic and Accident and Emergency after obtaining informed consent. A proforma was used to collect the required variables. Blood samples were drawn from the participants for biochemical analysis of HDL, TC, TG, LDL, and VLDL. Data was analyzed using statistical package for social sciences (IBM-SPSS) version 22.0 chicago II, USA. The lipid profile of the two groups was compared using student’s t-test. Pearson’s correlation and Spearman’s ranking were used to ascertain the correlation of abnormal lipid profile with continuous and categorical outcomes respectively. Statistic significance was set at P-value of <0.05.