BACKGROUND Pre-clampsia is a leading cause of maternal and fetal/neonatal morbidity and mortality worldwide. The early identification of patients with an increased risk for preeclampsia is one of the most important goals in obstetrics. Attempts have been made to evaluate various markers to predict pre-eclampsia, however none have been found reliable. Hence the quest for new reliable markers as predictors. The availability of highly sensitive and specific physiologic and biochemical makers would allow not only detection of patients at risk but also permit a close surveillance, an exact diagnosis, as well as simplified recruitment for future studies looking at therapeutic medications and additional prospective markers. Today, several markers may offer the potential advantage to be used, either singly or preferably in combination analysis as predictors, or diagnostic tools. Serum lipid is chosen in this study in early second trimester of pregnancy as a predictive tool for the occurrence of pre-eclampsia OBJECTIVE The study aimed at testing the hypothesis that women with abnormal serum lipid profile in early second trimester (14-20 weeks) have increased risk of developing preeclampsia. METHODOLOGY Serum lipid was evaluated among 170 pregnant women between 14 and 20 weeks of pregnancy, who attended antenatal clinic at Irrua Specialist Teaching Hospital (ISTH). This was done by Enzymatic colorimetric test and lipid clearing factor (LCF) in, and was correlated with the risk of pre-eclampsia/pregnancy-induced hypertension in the course of pregnancy.