Background: Pre-eclampsia is the most common medical complication of pregnancy yet the aetiology of the disease is poorly understood. The imbalance between free radicals and antioxidant vitamins may be a central feature in the pathogenesis and prevention of this disease. Aims/Objective: The study aimed at determining the serum level of vitamin C, beta carotenes and malonyl dialdehyde in pre-eclamptic women in Enugu, South East Nigeria. Study Design: This was a case control study of pre-eclamptic and healthy non-toxaemic pregnant women in Enugu, South East Nigeria. Materials and methods: The study was carried out at the University of Nigeria, Teaching Hospital Ituku-Ozalla, Enugu, Enugu State University of Science and Technology Teaching Hospital, Parklane, Enugu and Annunciation specialist hospital, Emene, Enugu. 82 pre-eclamptic and 82 healthy non-toxaemic pregnant women matched for age, gestational age and parity groups were recruited within one year and their serum samples analyzed for vitamin C, beta carotene and malonyldialdehyde spectrophotometricall