AIMS AND OBJECTIVES Obesity is becoming a global epidemic in both children and adults. The dramatic increase in the prevalence of obesity and its strong association with cardiovascular disease has resulted in unprecedented interest in understanding the effect of obesity on the cardiovascular system. The European society of cardiologists (ESC) and American College of Cardiology (ACC) consensus conference have codified the role of cardiac markers by advocating that the diagnosis of myocardial infarction be evidence of myocardial injury based on markers if heart is damaged in the appropriate clinical situation. The aim of this study is to determine and compare the serum levels of troponin I, creatine kinase MB and myoglobin in obese subjects and healthy controls. PATIENTS AND METHODS: Two hundred obese subjects aged between 20 and 40 years were studied along with two hundred age and gender-matched apparently healthy controls. The height and weight of the participants were measured and the body mass index calculated. 2 The serum troponin I, myoglobin and creatine kinase-MB were estimated.