Background: Pre-eclampsia remains a significant contributor to maternal and perinatal morbidity and mortality. Research into changes associated with the disease offers some hope into identifying predictive and prognostic factors. In recent times, serum leptin has attracted interest as a possible marker for the disease. Objectives:The overall goal of this study was to determine and compare the serum leptin levels in normotensive and preeclamptic pregnant women in DELSUTH. Methods: This was a prospective case-control study that was conducted at the Delta State University Teaching Hospital, Oghara, Delta State. Sixty three pregnant women who received antenatal care and developed pre-eclampsia were recruited into the study. For each selected preeclamptic, a matched normotensive were selected as control. Controls were matched for age, parity and body mass index (BMI). After counseling, 5mls of venous blood sample was taken for serum leptin and urine for albumin estimation. The serum leptin level was measured by radio-immunoassay (RIA) ELISA kits manufactured by GenWay Biotech Inc, San Diego, USA. Detailed history was taken and physical examination done. Statistical analysis was performed on SPSS. Differences in obtained values was tested for statistical significant using the Student’s t-test for continuous variables and chi square test for categorical variables.