INTRODUCTION Anaemia in pregnancy is a fairly common condition especially in the developing countries. Nutritional deficiency is the predominant cause of anaemia in pregnancy; with iron deficiency being the commonest factor. Iron supplementation in pregnancy is therefore still a topical issue. OBJECTIVE To determine the efficacy of weekly supplementation of oral iron against the current practice of daily supplementation in maintaining normal mean serum ferritin levels in non-anaemic pregnant women attending antenatal clinic at OAUTHC, Ile-Ife. METHODOLOGY This was an open randomized control trial in which 250 non-anaemic pregnant women were recruited from the antenatal clinics of OAUTHC, Ile-Ife at 20 weeks. They were randomized into two groups. One arm had 65mg of elemental iron daily while the other arm had 195mg of elemental iron once weekly. Ethical clearance for this study was obtained from the ethics and research committee of the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife. Normal serum ferritin level was set at 30-150ug/L. Continuous variables were compared with student ttest, while categorical variables were analyzed with chi square. The level of statistical significance was set at p < 0.01. The end points of the study were PCV, mean serum ferritin at term and birth weight