Sickle cell disease is a major health problem in Nigeria. It is associated with considerable morbidity (for example chronic anaemia and recurrent infections) and mortality. It is estimated that twenty-five percent of Nigerians carry one sickle cell gene and the homozygous state affects 2% of new-borns. There is significant disagreement on the iron status of subjects with SCA. While some researchers are of the opinion that children with SCA have normal to high iron stores and should not be ironsupplemented, others have shown that they can develop iron deficiency which will further worsen their anaemia, affecting their growth and neurocognitive functions. The level of iron in children with SCA in Zaria, northern Nigeria, is unknown. Knowing the level of iron stores using serum ferritin in children with SCA from the results of this study is hoped to influence patients’ management and policies towards reducing the morbidity and mortality from the complication of iron overloads or IDA in subjects with SCA. This study aims to determine the serum iron levels in children aged 1-5 years with sickle cell anaemia, and to establish any relation between the iron levels and anthropometric and haematological parameters in these children.