Introduction: Sickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure in these patients, but this is yet to be fully substantiated. Determination of their ovarian reserve will add to the body of knowledge on their reproductive health. Aim and objective: The aim of this study was to determine and compare the ovarian reserve of Nigerian women with and without sickle cell anaemia at the Lagos University Teaching Hospital (LUTH). Study Design: This was an analytical cross-sectional study carried out at the Haematology and Community Health Clinic of LUTH. Methodology: A total of 166 consecutive consenting women, who met the selection criteria, were recruited for the study. The study population consisted of two groups matched for age; 83 women with HbSS and 83 women with HbAA. Their serum levels of Anti- Mullerian Hormones (AMH) were determined using Enzyme-linked immunosorbent assay (ELISA) method (Calbiotech Inc. USA, Catalog no AM448T). Relevant data were obtained using a study-specific clinical report form. Data entry and statistical analysis were performed using IBM SPSS version 23.0. Student’s t-test was used to compare the continuous variables while Pearson’s Chi-square test was used to test association between categorical variables and the phenotype status. Univariable and multivariable linear regression analysis was conducted to determine the predictors of AMH.