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In endemic countries, like Nigeria, HBV infection occurs mainly during infancy and early childhood, with mother to child transmission being a major route of chronic HBV infections. This study was carried out to determine the prevalence of Hepatitis B and C virus infection, the coinfection rate among pregnant women in Ibadan South Western Nigeria and to identify the various risk factors associated with infection. A hospital-based cross-sectional study was carried out at the ante-natal clinic of the University College Hospital Ibadan. One hundred and eighty pregnant women were recruited from March to August 2013, and were tested for Hepatitis B surface antigen (BIORAD FRANCE) and anti-HCV antibody (DIAPRO Italy) using third generation ELISA. Positive HBsAg samples were tested for other HBV serological markers and serum HBV DNA were detected using PCR. Sero-positive HCV samples were tested for Serum HCV RNA. Their biodata were obtained using a pretested structured questionnaire to establish the sociodemographic characteristics and presence of possible risk factors. The prevalence of HBsAg was 8.3% and 1.7% for anti-HCV antibody. There was no HBV and HCV co-infection in this study. Out of the fifteen women sero-positive for Hepatitis B virus, four (26.7%) were positive for HBeAg, eight (53.3%) were positive for HBeAb, three (20%) were negative for both HBeAg and HBeAb, all had total HBcAb (100%) and thirteen (86.7%) had HBV DNA in their serum. The mean age of the respondents was 32.1 (SD 4.8 years), and the highest 2 HBV infection rate occurred in the 25-29 year age group while all women positive for Hepatitis C virus were under 35 years of age. Logistic regression revealed that women with multiple sexual partners were four times more likely to acquire HBV infection (OR- 3.987, P- value=0.026) while those who had their sexual debut at less than 15 years of age were twelve times more at risk for HBV infection (OR 11.996, P- value=0.022). Previous history of jaundice remained the most significant predictor of HCV infection after regression analysis (P- value=0.011). High infectivity of both HBV and HCV is widespread among infected women of child bearing age. Global best practices on prevention and control of Hepatitis B and C must be emulated in Nigeria.