Hepatitis B and C are among the many transmissible viral infections which cross the placenta to infect the fetus. Several studies demonstrate that sexual, household, occupational and vertical transmission are important mechanisms. This is a descriptive cross sectional study of the seroprevalence of hepatitis B surface antigen and hepatitis C viral antibodies in pregnant women attending the antenatal booking clinic of Irrua specialist Teaching Hospital. The clinical and epidemiological correlates for hepatitis B and C in pregnancy were also identified 205 pregnant women who came for antenatal booking were recruited into this study. Of these, 6.8% (n=14) were seropositive for hepatitis B surface antigen (HBsAg) while 3.9% (n=8) were seropositive for hepatitis C viral (anti-HCV) antibodies The significant risk factors for HBsAg seropositivity were history of multiple sexual partners and presence of tattoo/scarification marks (p<0.05). There was no significant association with respect to a history of jaundice or contact with a jaundiced patient, previous blood transfusion, intravenous drug abuse or sharing of sharps, previous surgery, episiotomies or dilatation and curettage or a husband with history of multiple sexual partners (p>0.05). None of the risk factors were significantly associated with hepatitis C viral antibody seropositivity. There was no significant association between HIV and hepatitis B or C infections ii Universal antenatal screening for HBsAg and immunization of all newborn and those at risk of hepatitis B is recommended while selective screening for anti-HCV antibodies on the basis of risk factors may be a viable option. Health education aimed at reducing risk factors is advocated