Aim. To screen for chronic simple glaucoma among persons aged 40 years and above at the General Outpatient Clinic of the Federal Medical Centre Keffi, Nasarawa State. Materials and Methods: This was a clinic-based descriptive cross-sectional study carried out from January to March 2013 at the General Outpatient Clinic. New patients aged 40 years or older visiting the Outpatient Clinic were consecutively selected. They were interviewed with questionnaires to obtain their demographic characteristics, ocular complaints and duration. The participants further had ocular examination including visusal acuity assessment, anterior segment examination and limbal anterior chamber depth measurement using the van Herrick technique. The central corneal thickness and intraocular pressure were measured using ultrasound pachymeter and tonometer respectively. Participants had fundoscopy and those with suspicious vertical cup-disc ratio (VCDR) and raised intra-ocular pressure (IOP) subsequently had fundus photograph for objective assessment of their vertical cup-disc ratio. The relationship between central corneal thickness and intraocular pressure of the participants was also ascertained in this study. Result: A total of 336 persons were examined of which 166 were males and 170 were females. The mean age of the participants was 51.6±10.6 years with a range of 40-95 years. The incidence of chronic simple glaucoma was 4.2%. Age and gender of the participants were not statistically significantly associated with CSG incidence (P= 0.306 vs 0.554 respectively). The central corneal thickness range was 425-632um with a mean of 556.3+ 28.4 um. Males had thicker mean CCT (559.3± 26.4 vs 556.7 ± 26.8 um) but this was not statistically significant ( P = 0.318), also, age did not show any statistically significant relationship with CCT ( P = 0.918). The normal mean IOP was 14.6 +3.9 mmHg with a range of 4-21 mmHg. Age and gender did not show any statistically significant relationship with IOP (P = 0.081 and 0.551 respectively). There was no statistically significant relationship between CCT and IOP ( P = 0.153). Conclusions. This study found a high incidence of CSG in the general outpatient department of FMC Keffi. The lack of statistically significant relationship between CCT and IOP is surprising and down plays the need for CCT consideration for accurate IOP measurements.