Background There is burgeoning data on the intricate relationship between religion and mental health worldwide, except in Africa in general and Nigeria in particular, where there is paucity of data about the relationship between religious coping and outcome measures (e.g., quality of life, severity of psychopathology and social recovery) of out-patients with schizophrenia. These data are necessary to patients, caregivers and clinicians in recognizing and promoting positive religious resource that will improve outcome of a condition that is hitherto considered a disabling illness with little or no hope for recovery. Objectives (i) To describe the pattern of religious coping practices and orientation of outpatients with schizophrenia, in Federal Neuropsychiatric Hospital, Enugu, in the preceding twelve months using religious coping scale (R-COPE) and religious orientation scale (R-ROS) respectively (ii) To determine the possible association between the religious coping practices and orientation; and the quality of life and social functioning among the study group (iii) To determine the correlation between the socio-demographic variables and quality of life among the study group with varied religious practices and (iv)To determine the association between the level of psychopathology using the brief psychiatric rating scale (BPRS) and religious coping and orientation of outpatients with schizophrenia in Federal Neuropsychiatric Hospital, Enugu, in the preceding twelve months. Method A total of 422 out-patients at the Federal Neuropsychiatric hospital, Enugu, that met the stringent criteria for schizophrenia were recruited into the study over a study period of 16 weeks. Standard instruments were used to measure religious coping (Brief Religious coping-Brief RCOPE), Religious orientation (Religious Orientation Scale-Revised-ROS-R), quality of life (World Health Quality of Life BREF-WHOQOL-BREF), severity of psychopathology (Brief Psychiatric Rating Scale-BPRS) and social functioning (Social and Occupational Functional Scale-SOFAS). Data were analysed using the statistical package for social sciences (IBM-SPSS) version 20. ii Relationship between religiosity measures and social functioning, quality of life and severity of psychopathology were assessed using Pearson’s correlation. Results Majority of the participants were young (mean age 37.46±9.57 years), never married (64.9%), of Igbo tribe (97.6%) and of Christian faith (98.3%). Participants were predominantly on typical antipsychotics (40.0%). Out patients with schizophrenia utilized mostly positive religious coping (mean Brief RCOPE score 13.05, CI 8.78-17.32 versus 6.74, CI 0.74-12.74), more intrinsic religiosity. There is weak positive significant correlation between measures of religiosity (religious coping and orientation) with quality of life and social functioning (r=0.1, p=0.009). Occupation, positive religious coping and intrinsic religiosity were found to be the predictors of quality of life, while religious orientation predicted religious coping. Mild symptom severities were seen in schizophrenia patients with positive religious coping and intrinsic religious orientation. This was however, not statistically significant (p > 0.05). Conclusion Findings from this study support vast majority of research that suggests that religious beliefs and practices as well as occupation are associated with better outcome among outpatients with schizophrenia; and highlight the importance of religion as a significant coping strategy