Studies have shown that allergens are important sensitizing agents in asthma. The relationship between various allergy markers has not been documented in Nigeria, although asthma is common. This study was therefore designed to investigate this relationship. Eighty adult asthmatic and 20 control subjects were recruited for this study. Blood sample was taken for specific IgE, total IgE and eosinophil count. Skin prick test (SPT) to 8 common allergens was performed on all subjects. Sixty five percent of the asthmatic patients had positive SPT reaction to at least one allergen. Dermatophagoides pteronysinnus [HDM] sensitization was the most common, occurring in 45% of asthmatics. Specific IgE was positive in significant proportion of asthmatics which showed positive reaction to SPT, with the same allergen, the highest being observed with HDM, occurring in 86% of the asthmatics. There was a positive correlation between the weal diameter of SPT and concentration of specific IgE in one of the 3 allergens tested (r = 0.554, p = 0.01 for HDM). A significant elevated total IgE and eosinophilia were observed among the asthmatics when compared to the controls. At least one positive parameter of atopy was found in 95% of the asthmatics. In 46% of the asthmatics, all the 3 parameters of atopy were found to be positive. The study revealed that though SPT was found to be the most cost benefit parameter of atopy , yet specific IgE assay may serve as an alternative to SPT in future in this environment