Background: The threat of blindness and the burden of treatment are very real challenges for patients diagnosed with glaucoma and may evoke a psychological response or distress that has impact on the visual outcome and lifestyle of the patient. The study aimed to identify the relative frequency and determinants of psychological distress in adult (aged ≥18 years) glaucoma patients attending Glaucoma Clinic in Ahmadu Bello University Teaching Hospital (ABUTH), Zaria with a view to making recommendations for improving the clinical care offered to glaucoma patients. Methods and Materials: The study was a descriptive, hospital-based study of adult glaucoma patients attending Glaucoma clinic in ABUTH, Zaria. Consecutive respondents were evaluated for socio-demographic characteristics, ocular status, severity of glaucoma using a closed-ended interviewer-based questionnaire as well as the level and type of psychological distress (characterized by symptoms of anxiety and/ or depression) using the Hospital Anxiety and Depression Scale (HADS) questionnaire. Results: A total of 200 adult Glaucoma respondents were recruited. The relative frequency of anxiety and depression was found to be 29% and 30.5% respectively. Longer duration since glaucoma diagnosis and Prostaglandin analogues usage were found to be statistically associated with anxiety, while being unmarried, Christianity, alpha agonists usage and longer duration since glaucoma diagnosis were significantly associated with depression. Other ocular parameters did not show statistically significant association with either anxiety or depression