Previous studies have noted that co-morbidity of psychiatric disorders in chronic medical conditions often impair treatment compliance, worsen disease progression as well as Quality of Life (QOL). End Stage Renal Disease (ESRD) belong to this group of conditions, but has not received much research attention with respect to its association with psychiatric disorders in Nigeria. This study assessed the prevalence of psychiatric disorder as well as quality of life of ESRD patients in selected hospitals of Lagos metropolis. The subjects were made up of 100 patients selected by systematic random sampling who attended renal clinics and dialysis centres in Lagos University Teaching Hospital and Gbagada General Hospital. The instruments used include: Socio-demographic/clinical questionnaire, Hospital Anxiety and Depression Scale (HADS), World Health Quality of Life assessment instrument (WHOQOL-BREF) and the Schedule for Clinical Assessment in Neuropsychiatry (SCAN). Data obtained were analysed using SPSS-16 to generate frequency tables, cross tabulations, chi-square tests and logistic regression analysis. Fifty five (55.0%) of the subjects were males. The mean age of the subjects was 41.87 (±10.87) years. Majority of the subjects were married (64.0%), a third (33.0%) had secondary school education while a large proportion (56.0%) were unemployed. Twenty eight (28.0%) subjects were diagnosed with psychiatric disorder based on SCAN. Majority of the subjects diagnosed with psychiatric disorder were females (53.6%) and married (64.3%). Psychiatric disorder was significantly associated with unemployment status (X2= 13.935, p <0.001), financial constraint as a reason for not having renal transplant (FET= 13.136, p <0.005), poor overall quality of life (X2= 8.051, p=0.005) and poor social relationship domain QOL (X2= 22.217, p <0.001). However, unemployment status (OR=5.589, p <0.05), poor overall QOL (OR=4.675, p <0.05) and poor social relationship domain QOL (OR=12.265, p <0.001) were the factors that were predictive of psychiatric disorder. Poor QOL was significantly associated with unemployment (X2= 7.040, p <0.01 for overall QOL and X2= 4.398, p <0.05 for social relationship domain), past dialysis history (X2= 4.823, p <0.05 for physical domain and X2=4.119, p <0.05 for social relationship domain) and financial constraint as a reason for not having renal transplant (FET= 23.197, p <0.001 for social relationship domain and FET= 8.240, p <0.05 for the environmental domain). Unemployment status (OR=10.511, p <0.05) and past dialysis history (OR=9.148, p <0.05) were predictive factors of poor QOL. In conclusion, a significant proportion of ESRD patients had psychiatric disorder and poor QOL. Social problems like unemployment and financial constraint predicted the presence of psychiatric disorder in the subjects. Prompt identification and treatment of mental disorders as well as the management of psychosocial problems in ESRD patients should be integrated into their management intervention and this could improve their QOL. The findings were discussed and the limitations of the study were highlighted.