Cerebral Malaria (CM) is one of the major complications of malaria and a leading contributor to death among children in sub –Saharan Africa. An increasing pattern of the burden of CM has been described in South-Western Nigeria. The study of recent pattern of presentations and outcome is highly essential even in the face of improved awareness and control measures mounted against malaria locally and globally. The knowledge of relationship between the clinical features, laboratory findings, and outcomes of cerebral malaria will help to predict the prognostic significance of these findings either singly or in combination as it relates to the clinical outcome even by the bedside. This study aims at determining the prognostic indicators of cerebral malaria in children aged six months to twelve years in Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital Ogbomoso. Children aged 6 to 12 years who fulfilled World Health Organisation (WHO) case definition for cerebral malaria were recruited into this study. The sociodemographic, clinical and laboratory parameters were studied. The expected clinical outcomes were survival without neurological sequelae, with sequelae and death. Data analysis was done using Chi-square, relative risk and odd-ratio for association between clinical presentation and clinical outcome. Stepwise logistic regression analysis was employed to determine the predictors of prognostic significance among various clinical parameters. Fifty children with Cerebral malaria were admitted during the period of study with prevalence rate of 4.1%. The ages ranged between 1and 12 years with a mean age of 4.86 ± 3.16 years and 60% were aged less than five years.