BACKGROUND: Antiphospholipid antibodies (APLA) are heterogeneous group of circulating antibodies against anionic phospholipids. They have been associated with a number of obstetric complications however their role in the pathogenesis of preeclampsia has remained an issue of controversy. AIMS: The aim of this study is to determine the prevalence of antiphospholipid antibodies in preeclampsia among women presenting to the University of Benin Teaching Hospital (UBTH) Benin City. OBJECTIVES: To determine the frequencies of Lupus anticoagulants and Anticardiolipin antibodies in preeclampsia; to determine the association between APLA and preeclampsia; to determine the pregnancy outcome in APLA positive women with preeclampsia and to determine the relationship between platelet counts and APLA. This is with a view to recommending screening for APLA to women at risk of preeclampsia. MATERIALS AND METHODS: This is a cross sectional case control study. Consecutive pregnant women diagnosed of preeclampsia and age-parity matched normal on-going pregnant women were recruited as participants for the study. Antiphospholipid antibodies were assayed using dilute Russel viper’s venom (DRVV) LA kits (LA screen kits and LA confirm kits) and total anticardiolipin antibody enzyme linked immunosorbent assay (ELISA) based assays. Haematological parameters were analyzed with haematology automated analyzer MODEL SYSMEX KN21, Japan.