Sickle cell disease is a genetic disorder of haemoglobin characterized by chronic anaemia due to ongoing haemolysis. The majority of SCA patients live in low and middle income countries, coincidentally, these are the areas where intestinal helminthic infections are commonly found especially among children. Intestinal helminthic infection in children with SCA may be associated with increased morbidity. The objectives of this study were to determine the prevalence of intestinal helminthic infections among children with SCA and to compare the haematological profiles and frequency of vasoocclusive crises in infected and non-infected children with SCA in Federal Teaching Hospital Abakaliki. A hospital based cross sectional study involving 120 children with SCA from age 2 to 18 years was carried out over a period of 3months. Questionnaire was used to collect data on the likely predictors of intestinal helminthic infection and episodes of VOCs. Fresh stool and blood samples were collected from the subjects. Stool was analysed for intestinal helminthic infection using the Kato-Katz method while complete blood count was done using automated method. The association between the potential predictors of helminthic infection and presence of intestinal helminthic infection was determined. Those that have significant association with intestinal helminthic infection were further analysed using multivariate logistic regression to determine the adjusted odds ratio and confidence intervals. The median values of the haematological profiles and the mean episodes of VOCs were compared between infected and non-infected subjects Sickle cell disease is a genetic disorder of haemoglobin characterized by chronic anaemia due to ongoing haemolysis. The majority of SCA patients live in low and middle income countries, coincidentally, these are the areas where intestinal helminthic infections are commonly found especially among children. Intestinal helminthic infection in children with SCA may be associated with increased morbidity. The objectives of this study were to determine the prevalence of intestinal helminthic infections among children with SCA and to compare the haematological profiles and frequency of vasoocclusive crises in infected and non-infected children with SCA in Federal Teaching Hospital Abakaliki. A hospital based cross sectional study involving 120 children with SCA from age 2 to 18 years was carried out over a period of 3months. Questionnaire was used to collect data on the likely predictors of intestinal helminthic infection and episodes of VOCs. Fresh stool and blood samples were collected from the subjects. Stool was analysed for intestinal helminthic infection using the Kato-Katz method while complete blood count was done using automated method. The association between the potential predictors of helminthic infection and presence of intestinal helminthicinfection was determined. Those that have significant association with intestinal helminthic infection were further analysed using multivariate logistic regression to determine the adjusted odds ratio and confidence intervals. The median values of the haematological profiles and the mean episodes of VOCs were compared between infected and non-infected subjects.