PREVALENCE OF ANAEMIA OF CHRONIC DISEASE, AND ESTIMATION OF SERUM ERYTHROPOIETIN LEVELS IN PATIENTS WITH CHRONIC DISEASE IN JOS UNIVERSITY TEACHING HOSPITAL (JUTH).
Objective:
The objective was to document the laboratory characteristics
Anaemia of Chronic Disorders including determination of
of
serum EPO Levels in these patients.
Design:
Subject:
What is cross – Sectional descriptive study
215 patients consisting of 90 as controls (patients that did not
disease) and 125 patients that had chronic
have chronic
diseases who presented in the outpatient department
clinics
Method:
of the Jos University Teaching Hospital were recruited.
Subject biodata and focused clinical history were recorded, full blood count, serum iron, serum ferritin
and serum EPO were performed) on all subjects as described by standard methods and according to kits
manufacture’s instructions.
Result: of the 125 with chronic disorders only 90 72% had anaemia (PVC<33%).of the 90 that had
anaemia 82 (82/125 = 65.5%) had laboratory features of ACD (low sermon iron and high ferritin levels).
The serum iron and ferritin levels of the controls (18.98+165 respectively) were significantly different
from that of the 82 subject with ACD (6.8+242 respectively) )P+0.00,P+ 0.00 respectively).
Appropriateness of EPO response to anaemia was determined by establishing an exponential
relationship between EPO levels of controls and Hb levels of control. Log EPO +22.446-0.11 x Hb g / dl
was establish EPO levels of anaemic subjects by putting their Hb concentrations into the equation. The
resulting EPO values were regarded as predicted values. A ratio of observed value over predicted values
(O/P ratio) were calculated. O/P ratio <0.8 was accepted as inappropriate response. Patients with ACD
had significantly higher (32.1+10.1), P+0.00. Thirty (33%) of the 90 anaemic patients had OPratio less
than 0.8 (<0.8). 4 p2 The serum ferritin levels of those
With inappropriate EPO response (515.5+268.01) was significantly higher than those with appropriate
response (395.83+220.20) P = 0.025
CONCLUSION
65.5% of patients with chronic disorders had laboratory features of ACD. EPO response was
inappropriate in 33% of patients with ACD.