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PREVALENCE AND FETOMATERNAL OUTCOME OF PLACENTAL MALARIA IN ASYMPTOMATIC PATIENTS AT DELIVERY IN UNIVERSITY OF PORT HARCOURT TEACHING HOSPITA

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Supervisor: PROF. C. T JOHN
Faculty: OBSTETRICS AND GYNAECOLOGY
Month: 11
Year: 2011

Abstract

Background: Malaria is an important public health problem in sub-Saharan Africa especially in pregnancy due to its association with poor fetomaternal outcome. Pregnant women are particularly prone to malaria due to the depressed immunity that occurs physiologically in pregnancy. This is worsened by the high level of poverty, illiteracy and poor health care delivery system. Adequate preventive measures as well as effective case management are imperative in curbing the menace of malaria in pregnancy. Even women who received malaria chemoprophylaxis in pregnancy are still prone to placental malaria due to sequestration of the malaria parasite in the placenta. Placental malaria affects the efficacy of the placenta resulting in premature delivery, low birth weight and increased perinatal mortality. OBJECTIVES: The main objective of this study was to determine the prevalence of placental malaria in asymptomatic patients and also to compare the fetomaternal outcome between affected and unaffected women. Methodology: This study was a prospective cross-sectional study of 210 booked antenatal women who delivered at the University of Port Harcourt Teaching Hospital (UPTH). Participants were recruited during labour. All consecutive women at labour who met the eligibility criteria and consented for the study were selected. A well designed proforma was used to obtain sociodemographic information from the participants. Each participant blood sample was collected and examined for the presence of malaria parasite and also her baby’s umbilical cord and placenta blood samples were also examined for malaria parasite. In addition, maternal and cord blood haemoglobin concentration were also determined. Statistical analysis of generated data was carried out using SPSS version 16 software package. Chi square test was used to compare categorical variables while Student ‘t’ test was used to compare continuous variables between affected and unaffected women and values of P < 0.05 was considered significant.

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