Background: Over the years, epilepsy has been associated with mental illness, especiallydepression. However, oftentimes in the management of epilepsy in children, the presence of co morbid depression is not sought for neither is it diagnosed nor is treatment initiated. Undetected, under-detected and un-treated depression in the children with epilepsy is a public health problem that requires proactive measures. Therefore, there is a need to determine the burden of occurrence of depression in children with epilepsy in other to draw attention to this issue. Aim: The primary objective was to investigate the prevalence of depressive disorders in children with epilepsy being managed at the out-patient department of the university of Port Harcourt Teaching Hospital, South-South, Nigeria as well as establishing the correlates and predictors. Method: This was a crosssectional studyinvolving 380 children with epilepsy who were consecutively recruited from thepeadiatric neurology clinic of the University of Port Harcourt.Data was collected using a questionnaire with socio-demographic andclinical information, along with Centre for Epidemiological Studies Depression Scale for Children (CES-DC) and Diagnostic Interview Schedule for Children (DICA1V). Statistical Package for the Social Sciences (SPSS) Version 20, was used for analysis and test of significance was set at p<0.05. Bivariate and multivariateanalysis wasconducted to determine correlates of depression. CES-DC depressive cutoff score was determined by intersection of the sensitivity and specificity curves. Result: The depressive cutoff point of CES-DC was 21 and of the 380 respondents, 52 (13.7%) had scores greater than 21. The apparent prevalence of depression was 30.8% while the true prevalence was15.2%.Socio-demographic factors that were significantly associated with depression included age (with children aged 9-11 years having the highest rate of depression), marital status of mother, living arrangement and family history of epilepsy/ mental illness. Other socio-demographic variables that were significant were the birth position of respondent, number of siblings, knowledge about health condition, academic performance and areas of life affected by epilepsy . Epilepsy related factors that were statistically significant risk factors for depression included, seizure type, duration of illness, AED currently used, AED initially used, concurrent use of 2 or more AED, frequency of seizure and age at diagnosis . Following the Logistic regression analysis of the 20 identified correlates of depression,three were statistically significant at p<0.05. These variables were mother’s marital status (odd’s ratio of 15.787, 95%CI : 4.114- 60.584, p value = 0.001). Family history of epilepsy (odd’s ratio of 18.5 and 95% CI 3. 1-111.11 p value= 0.001) and the frequency of seizure,(odd’s ratio of 9.898 and 95% CI 2.598- 37.716,p value =0.001) were the other predictors. Conclusion: The occurrence of depression among children with epilepsy in this study is not uncommon. Mother’s marital statuses, family history of epilepsy and seizure frequency are predictors of depressive co morbidity among the study population. There is therefore the need for inclusion of mental health care in the routine management of children with epilepsy