Introduction Pre-eclampsia being a major cause of maternal and perinatal morbidity and mortality still has no cure aside delivery. Prediction of the disease using biomarkers is a novel approach in the research of this condition and malondialdehyde a secondary product of lipid peroxidation holds promises in this regard. Aim To compare malondialdehyde levels in pre-eclamptic women and normotensive pregnant women at the Federal Medical Centre, Owerri and correlate it with disease severity. Methodology A cross sectional case control study involving fifty-six pre-eclamptic pregnant women and fifty-six matched normotensive pregnant women presenting at the Obstetrics and Gynaecology Department of Federal Medical Centre Owerri. Ethical clearance was obtained from the institution and consent obtained from individuals before recruitment. Five millilitre of venous blood was obtained from participants and assayed for malondialdehyde using Enzyme Linked Immunosorbent Assay. Blood sample was also analysed for low platelet count as a feature of disease severity among the cases. Data analysis This was done using IBM SPSS statistical package version 20. Mean between groups were found and correlation between malondialdehyde and features of disease severity evaluated