BACKGROUND: Falciparum malaria in pregnancy is an important cause of maternal and perinatal morbidity and mortality in malaria endemic areas. Pregnant women in endemic areas are at risk of placental malaria which may be asymptomatic and therefore undetected and untreated. Thus, it is imperative to determine the association between placental malaria and pregnancy outcome in asymptomatic women at delivery. OBJECTIVE: To determine the association between placental malaria and pregnancy outcome in asymptomatic women at delivery. METHODOLOGY: Two hundred and six eligible women that were asymptomatic for malaria presenting in labour were enrolled at Federal Teaching Hospital (FTH) Ido-Ekiti, Ekiti State, Nigeria. A structured proforma was used to obtain relevant data of the parturients including sociodemographic characteristics, parity, gestational age, use of intermittent preventive treatment of malaria in pregnancy (IPTp) and insecticide treated nets (ITNs), and treatment for malaria in index pregnancy. Pre-delivery, maternal peripheral blood was taken for packed cell volume (PCV). Post-delivery, placental biopsy was taken for histologic evidence of placental malaria. The newborn was weighed within 1 hour of delivery. Data were analyzed using SPSS version 26 and binary logistic regression analysis was performed.