INTRODUCTION: Pelvic organ prolapse (POP) when symptomatic, could be highly distressing, particularly with increasing severity of prolapse. Unfortunately, the condition is undiagnosed and unreported by affected women, resulting in long term sufferings. Its true incidence using validated method of examination in a wider range of population of women needs evaluation in our environment, and identification of determinants will facilitate preventative measures and early diagnosis. AIM: To determine the prevalence of the different Pelvic Organ Prolapse Quantification(POPQ) stages of pelvic organ prolapse, correlate these stages with clinical symptoms and identifying the determinants of pelvic organ prolapse among women in Ile-Ife, Nigeria. METHODS: This was a cross sectional study of consecutive, consenting four hundred women (aged 22-74years) attending the Gynaecology, General Outpatient, Family Planning, and WellWoman clinics at Obafemi Awolowo University Teaching Hospitals Complex, Ile- Ife, Nigeria. The subjects’ relevant biodata and selected determinants of POPQ were documented in a purpose designed and pre-tested questionnaire, and the International Consultation on Incontinence Questionnaire Vaginal Symptoms (ICIQ-VS) was administered. Thereafter, the POPQ examination was performed in semi-recumbent position, using the IUGA stix for measurement. The obtained data were analysed using IBM SPSS version 20.0. The prevalence of the different POPQ stages was determined and expressed as proportions. Receiver Operating Characteristic (ROC) analysis was performed to determine the sensitivity, specificity and ideal cut-off score of ICIQ-VS for predicting POPQ stages. Logistic regression analysis was then performed to identify the significant determinants in this population.