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PATTERN OF DERMATOLOGICAL DISORDERS AMONG DIABETIC PATIENTS IN OBAFEMI AWOLOWO UNIVERSITY TEACHING HOSPITAL COMPLEX,ILE-IFE,NIGERIA.

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Supervisor: Professor O. Onayemi Dr. {Mrs.} O.A. Olasode
Faculty: INTERNAL MEDICINE
Month: 5
Year: 2011

Abstract

The study was carried out to determine the prevalence and pattern of dermatological disorders among diabetic patients in Obafemi Awolowo University Teaching Hospital Complex Ile–Ife, and to assess the relationship between duration of diabetes, glycaemic control and the dermatological disorders. A purpose designed questionnaire was used to obtain the following information from the subjects; age, gender, occupation, educational qualification, duration of diabetes, family history of diabetes mellitus, type of treatment received. History of present complications of diabetes was sought and the subjects were examined from head to feet for presence of skin lesions. The lesions seen were documented and specimen taken and sent when necessary to the laboratory for microscopy and culture. Skin biopsy was also taken for confirmation of diagnosis when necessary. The weight and height of the subjects were measured and used to calculate the body mass index (BMI). Average of three monthly fasting blood glucose and two hours post prandial glucose was calculated for all subjects to assess blood glucose control. Glycated haemoglobin was measured for one hundred and fifty seven subjects and was also used to assess glycaemic control. A total of three hundred and fifty five subjects were involved in this study. One hundred and ninety two (54.1%) subjects were females and one hundred and sixty three (45.9%) were males. Age range of the subjects was 16 – 89 years with mean of 59.76 years. Duration of diabetes ranged from 1 – 30 years with mean of 4.91 years. The prevalence of dermatological disorders found in this study was 73%. Infectious dermatoses (39.2%) especially fungal infections (35.4%) constituted the bulk of the dermatological disorders seen in this study. Other disorders seen included pruritus (16.7%), diabetic dermopathy (14.8%), acanthosis nigricans (4.9%), diabetic thick skin (4.0%), bacterial infection (3.6%), diabetic ulcer (3.6%), skin tags (3.0%), tendinous xanthoma (2.6%), vitiligo (2.2%), erysipelas like erythema (2.2%), sclerederma diabeticorum (2.2%), idiopathic guttate hypomelanosis (1.6%) insulin lipohypertrophy (0.9%), seborrheic dermatitis (0.45%), herpes zosters (0.45%), viral wart (0.23%), lichen simplex chronicus (0.23%), keloids (0.23%), insulin lipoatrophy (0.23%), and diabetic rubeosis (0.23%). Rare cutaneous disorders linked to diabetes such as granuloma annulare, acquired perforating disorder, necrobiosis lipoidica and bullosis diabeticorum were not seen in this study. Poor glycaemic control was a major determinant of presence of dermatological disorders among the subjects in this study. Disorders were seen in higher frequency among subjects with poor glycaemic control (p < 0.01). This is especially so for infective dermatological disorders because poor glycaemic control alters immune status and predisposes patients to infections. Dermatological disorders were also seen more among subjects who had been diabetic for less than or equal to five years (p=0.042). This may be incidental because majority of the subjects in the study (67.3%) have been diabetic for just less than 5 years. Factors such as age, gender, occupation, type of diabetes did not contribute to the presence of dermatological disorders among diabetic population (p>0.05). Other complications of diabetes such as neuropathy and hypertension, were seen in higher frequency among diabetic patients with dermatological lesions, though they did not show any significant statistical association except hypertension (P = 0.026). This study therefore showed high prevalence of dermatological disorders in patients with diabetes mellitus and poor (suboptimal) glycaemic control was the major contribution to the presence of these disorders

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