AIM: To determine the pattern and determinants of corneal blindness in Ido local government area of Oyo state, south-west Nigeria. MATERIALS AND METHODS: The study was a population based cross-sectional study and was carried out between March and April 2014. A multistage sampling method with probability proportional to size procedure was used to select 1002 participants. The study involved administration of interviewer administered questionnaire and ocular examinations of the participants. RESULTS: There were 410 males and 592 females; their age range was 5-92 years with a mean age of 43 (±17) years. Eleven subjects (13 eyes) were found to have corneal blindness in the survey given a prevalence of 1.1%. Corneal blindness accounted for 9.6% and 20.4% of bilateral and unilateral blindness respectively in the survey. The commonest cause of corneal blindness was microbial keratitis (36.4%), followed by trauma (27.2%). Post-eye surgery, measles, allergic keratoconjunctivitis and pterygium accounted for 9.1% each. Corneal blindness from trachoma, onchocerciasis, leprosy and congenital eye diseases were not found in the survey. The prevalence of corneal blindness was greater among male respondents, older age groups, farmers and subjects with low educational status. Seven (64%) of the subjects with corneal blindness visited patent medicine sellers for treatment at the onset of the diseases because most of them felt they were closer and readily available to them. Only two participants with corneal blindness consulted an eye specialist during the early course of the disease.