Background Post caesarean section pain is a commonly feared and distressing outcome of caesarean section. The negative effects of not relieving postoperative pain are enormous and even worsened in post caesarean section patients. Unimodal analgesia uses one analgesic technique/drug while multimodal analgesia uses different analgesic drugs/techniques to achieve better analgesia. Ideal and effective post caesarean section analgesic remains a challenge especially in resource poor setting where options are limited. The aim of this study was to compare the effectiveness of our departmental analgesic protocol of Pentazocine alone with multimodal combination of Tramadol-Diclofenac for the management of post caesarean section pain in Central Hospital, Benin City. Research methods This double blind, randomized controlled trial of post caesarean section pain management included 78participants who had elective caesarean section under spinal anaesthesia in Central Hospital, Benin City. The participants were randomly allocated to two groups to receive either intramuscular Pentazocine 30mg (1ml) 6hourly and placebo rectal suppository 8hourly OR Tramadol 50mg (1ml) 6hourly and Diclofenac 50mg rectal suppository 8hourly for 24hours The primary outcome was post caesarean section pain relief which was assessed using visual analog scale in the first 24hours. Secondary outcome were side effects (sedation, nausea, vomiting) and patient’s satisfaction. Sedation was assessed using a sedation score while satisfaction was assessed using Likert scale. The data was be analyzed with SPSS version 21. A p-value of <0.05 was considered statistically significant.