BACKGROUND Postpartum haemorrhage is a leading cause of maternal mortality despite active management of third stage of labour with oxytocin. It is important to note that standard use of uterotonic to control PPH may not always work. Addition of tranexamic acid may help in further reducing the volume of postpartum blood loss and incidence of postpartum haemorrhage. AIM To compare the efficacy of oxytocin only versus oxytocin with 1000mg of intravenous tranexamic acid in reducing postpartum blood loss following vaginal delivery METHODOLOGY This was a randomized controlled study involving 108 parturient with no apparent risk factor for PPH in University of Calabar Teaching Hospital, Calabar who were randomly grouped into two of 54 each. Group A received10 IU of oxytocin intramuscularly with 1000mg of intravenous tranexamic acid within one minute of having vaginal delivery of their baby. Group B received intramuscular oxytocin 10 IU only and served as the control group. Blood loss was assessed using BRASS V, and the difference in pre and postpartum packed cell volume level. DATA ANALYSIS The data obtained was tabulated and analyzed using the IBM statistical package for the social sciences, version 23 (Chicago II, USA). Mean difference and standard deviation (SD) were calculated. Categorical variables were presented as numbers and percentages. Chi-square test was used for qualitative variables while T-test was used for quantitative variables and relative risk (RR) was calculated. The level of significance was kept at p-value < 0.05.