Background: Misoprostol is an ideal agent for induction of labour in all clinical settings due to its relative inexpensiveness, stability at room temperature, and ease of administration by several routes .Many researches are now focusing on the optimal dosing regimen, timing, and routes of administration of misoprostol for optimal effect and safety. However, there is paucity of both local and global studies that compared the same equal and low dose misoprostol by the oral and vaginal route for induction of labour in term foetuses. AIM AND OBJECTIVES: To compare the efficacy and safety of 25ug of oral misoprostol with 25ug intravaginal misoprostol for induction of labour at term. The maternal and foetal outcomes of both routes were also compared. METHODS: 169 women with indication for induction of labour , were randomized into the oral group and the vaginal group. A total of 85 women swallowed 25ug of misoprostol in the oral group every 2 hours, while 84 women had 25ug misoprostol inserted into their posterior fornices every 6 hours in the vaginal group. Oxytocin augmentation was considered in each patient when indicated, 6 hours after the last dose. The main efficacy measures were induction – delivery interval , vaginal delivery rate within 24 hours and the number of additional doses of misoprostol required, while the safety measures included; cardiotocographic changes, foetal distress, Apgar scores less than 7 at 5 minutes and gastrointestinal symptoms in the mother, and genital tract lacerations. The parturient’s satisfaction with each route was assessed by the Likert’s scale.