Background: Ocular surface disease is a multi-factorial disease of the tear and ocular surface that results in symptoms of discomfort, visual disturbance and tear film instability with potential damage to the ocular surface. It is a major reason for visit to the eye clinic by the elderly. Glaucoma patients are presumably at a higher risk for developing ocular surface disease, as both diseases occur more commonly in older individuals. Objective: This study aims to determine the frequency of ocular surface disease and its impact on quality of life amongst glaucoma patients attending the Eye Clinic of the University College Hospital, Ibadan. Methods: This is a case series with analytical component. This study was carried out at the Eye Clinic of the University College Hospital Ibadan on 182 consecutive glaucoma patients. After a detailed ocular examination, each respondent completed an Ocular Surface Disease Index Questionnaire, Glaucoma Quality of Life-15 Questionnaire, they had Schirmer’s test and tear break up time evaluations and performed central visual field assessment.