Purpose:To determine the frequency of ocular manifestations of leukaemia and the risk factors for the development of these ocular disorders amongst patients at University of Benin Teaching Hospital Benin City, Nigeria. Material and Method: This is a hospital- based case control study from Sept 2014 to April 2015. Forty newly diagnosed leukaemic patients were enrolled into the study. Age and sex matched controls were drawn from healthy relatives of patients, staff, and students of University of Benin and children of University of Benin Staff School.They had Full Blood Count, Genotype, Fasting blood sugar and other tests done to exclude confounding factors such as diabetes mellitus, HIV and hypertension. All the study subjects were interviewed and had detailed ocular examination. Refraction was done where necessary. Clinical data from each individual was obtained using interviewer administered questionnaires. These were collated and analyzed using SPSS 20.