Aim / Objectives: To determine the pattern of ocular findings among newly diagnosed adult patients with pulmonary tuberculosis with HIV infection and those without HIV infection and to describe the pattern of ocular complications that may result from TB medications within a period of six months in three Directly Observed Treatment Short-Course (DOTS) Centres; Lagos University Teaching Hospital, Nigerian Institute of Medical Research and Mainland Hospital (otherwise known as IDH- Infectious Disease Hospital). Materials and Methods: A hospital based longitudinal cohort study conducted on both eyes of 210 enrollee aged above 18 years over a period of 6 months, between December 2016 and June 2017.Interviewer administered questionnaires were used to obtain data. Ocular examinations were carried out, intraocular pressures were measured, pupils were dilated and fundoscopy was done. Data was analysed using the Statistical Package for Social Sciences (SPSS) 20 and statistical significance was taken as p< 0.05. Results: Two hundred and ten patients were examined (131 males and 79females) , 70 from each centre -35 PTB+HIV and 35 PTB-HIV, with mean age38.1± 12.7 years. Presumed ocular TB was found in 2.4% of the patients; 8 eyes of 5 patients and they included: bilateral optic atrophy, bilateral anterior uveitis, monocular phlyctenulosis, bilateral proptosis and monocular choroidal granuloma. Eighty nine percent were not aware of ocular complications of TB and its treatment. PTB+HIV patients were noted to have accommodative failure. Transient opticneuropathy was observed in most patients while they were on regimen containing ethambutol. Conclusion: Visual impairment, ocular morbidity and blindness can result from tuberculosis and its treatment. Loss of vision may be prevented by high level of suspicion,monitoring forocular complications during treatment, early diagnosis and early treatment of TB.