Aim: To compare newly diagnosed normal-tension (NTG) and high-tension (HTG) primary open-angle glaucoma (POAG) patients, with normal controls, using colour Doppler imaging (CDI) technique at the Lagos University Teaching Hospital (LUTH), Idi-Araba, Lagos. Materials and Methods: The study was a case-control study carried out on 50 consecutively, consenting, newly diagnosed primary open angle glaucoma (POAG) patients (Glaucoma group) and 50 control subjects (control group). The glaucoma group comprised of 25 normal-tension (NTG) and 25 high-tension (HTG) glaucoma patients Both eyes of all respondents were studied (200 eyes). Approval from the Health Research Ethics Committee of the Lagos University Teaching Hospital (LUTH), Idi-araba, Lagos, was obtained. Routine eye examinations were done. A non-invasive ocular colour Doppler imaging (CDI) was performed on subjects in supine position using 7.5MHz linear away transducer, Toshiba 2000 model. The main outcome measures of Peak systolic velocity (PSV), End diastolic velocity (EDV) were obtained by finding the average of three readings each for the ophthalmic artery (AO), central retinal artery (CRA) and short posterior ciliary artery (SPCA). Resistance index (RI) of each of the three vessels was calculated from PSV - EDV/PSV. Data were analysed with Statistical Package for Social Sciences (SPSS) version 20.0 (IBM Inc., Chicago IL, USA) and statistical significance was defined at P<0.05. Data were collected over a 3-month period (mid-March to mid-June, 2017).