Background: Gestational trophoblastic disease (GTD) is a spectrum of proliferative disorders of the placental trophoblast with a range of histological appearances and clinical behaviours. It is reported to be commoner in the developing countries. Although its aetiopathogenesis is as yet incompletely understood, it is well established that early detection and prompt treatment lead to the preservation of normal health and fertility. Aim and Objectives: This study sought to determine the morphological pattern as well as the age and site distribution of the various forms of GTD histologically diagnosed in the University of Benin Teaching Hospital, Benin City, between January 2003 and December 2012. It is a hospital based, retrospective review utilizing materials from the archives of the Department of Morbid Anatomy, University of Benin Teaching Hospital. The parameters studied include the specific histological diagnoses, and the age and site distribution.