BACKGROUND: Malaria in pregnancy has a prevalence of 20% to 70% in Nigeria and is associated with several feto-maternal complications. It is better prevented than treated because of the physical and socio-economic impacts on the woman, her fetus, family and community. Monthly use of IPTpSP has been recommended by WHO to be more effective than two-dose regimen of IPTp-SP in preventing malaria in pregnancy. However, the use of two-dose regimen of IPTp-SP might be more affordable and have a better uptake in rural setting if found not to be inferior to monthly dose in its effectiveness as IPTp. OBJECTIVE: The aim of this study was to determine effectiveness of two-dose regimen of sulphadoxinepyrimethamine as intermittent preventive treatment (IPTp-SP) as compared to monthly dose regimen. METHODOLOGY A total of 130 participants completed the study with 66 in two doses group and 64 in monthly group. The study was a randomised controlled trial. Participants were followed up till delivery. Categorical variables were analyzed with Chi square test; reported as Risk Ratios (RR). The level of significance was set at p <0.05 and 95% confidence interval (CI).