BACKGROUND: Sexually transmitted infections constitute a public health problem and an increased risk for transmission of human immunodeficiency virus worldwide. It has been ranked among the top five diseases in developing countries, among adults. Syndromic management of sexually transmitted infections is based on symptoms and signs rather than on aetiologic diagnosis. It ensures that patients and partners are treated promptly and effectively at the point of first contact and subsequently makes treatment accessible and affordable to a large majority of population. OBJECTIVES: The objective of this study was to determine the effectiveness of the syndromic management of male urethral discharge, using laboratory method of assessment, in Jos North LGA, Plateau State, with specific reference to the level of acceptability of syndromic 1 management, the age and occupational distribution of male urethral discharge among the patients. RESULTS: A total of 200 male patients were recruited for this study of which 176 completed the study while 24 patients absconded. The mean age of the patients was 30.7 years with the peak age range of 21-30 (56.8%). Predominant occupation at risk was commercial motor cyclists (45.5%). There were two gonococcal isolates (1.1%) out of 176 urethral smears. The two gonococcal isolates were beta-lactamase producers, and were resistant to penicillin, erythromycin, ceftriaxone and doxycyclin but susceptible to ciprofloxacin and azithromycin with MICs of ≤0.39 μg/ml and ≤0.195 μg/ml respectively. Most of the tested drugs are routine drugs used for syndromic treatment. By laboratory method of assessment, 166 patients (94.3%) were effectively cured by first line syndromic drugs (ciprofloxacin, 500mg single oral dose and doxycyclin 100mg, twice daily for 7 days) while 10 patients (5.7%) were not. (x2 = 15.714, P = 0.000,df = 1). The cost of syndromic treatment was cheaper, 34.2% the treatment by aetiology. The average number of visits was once, and average waiting time was 1 hour. The data were analyzed in EPI INFO version 6.04. CONCLUSION 2 The cure rate of syndromic treatment was very effective (94.3%), by laboratory assessment. And the syndromic treatment of STI was very cost saving.