Background A lot of reservations have been expressed by researchers concerning the capability of general medical practitioners to display sufficient skills in the examination and treatment of vision problems. They maintain that time spent in teaching vision related clinical skills in the schools has been on the decline. Consequently there are doubts on the scope of knowledge and understanding of general medical practitioners on vision. Aim To evaluate the knowledge, attitude and practice of non-ophthalmic medical doctors on prevalent blinding ophthalmic diseases in Enugu with a view to generating data for eye health policy. Materials and method A total of three-hundred-and-ninety-one, (391), non-ophthalmic medical doctors took part in the study. Owing to the fact that majority of the doctors work in the tertiary institutions while a few were located in the primary and secondary sectors, all the consenting doctors in the primary and secondary institutions were interviewed, whilst those from the tertiary centres were selected by a simple random process. The participants were examined through a pre-tested questionnaire on the definition, symptoms, causes and treatment of cataract, glaucoma, and refractive error. They were also assessed on their attitude and practice regarding ocular examination, referral of such cases when necessary as well as determining eye structures they assessed in cases of cataract, glaucoma, and refractive errors.