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IS THERE A DIFFERENCE BETWEEN PREGNANCY OUTCOMES IN PREGNANT NIGERIAN WOMEN WITH BORDERLINE AND NORMAL AMNIOTIC FLUID INDICES AT TERM? A PROSPECTIVE COHORT STUDY

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Supervisor: PROFESSOR PETER N. EBEIGBE DR. OGBEIDE O. ANTHONY
Faculty: OBSTETRICS AND GYNAECOLOGY
Year: 2016

Abstract

Background: Ultrasound assessment of amniotic fluid volume has important implications in obstetric care. While the observation of diminished amniotic fluid volume has long been recognized as a predictor of adverse perinatal outcome, there is a paucity of information on the clinical significance and pregnancy outcomes associated with borderline amniotic fluid index. Aims: The aim of this study was to compare pregnancy outcomes of antenatal patients at term with borderline and normal amniotic fluid index at DELSUTH, Oghara and Central Hospital Warri. Objectives: The objectives of this study were to determine the pregnancy outcomes of women with normal Amniotic Fluid Index at term, the pregnancy outcomes of women with borderline Amniotic Fluid Index at term, any significant difference in the proportions of the outcome measures in women with normal amniotic fluid index and borderline AFI and based on the findings, make recommendations on the management of women with borderline AFI at term. Methodology: This study was a prospective cohort study conducted at Delta State University Teaching Hospital, Oghara and Central Hospital, Warri. A total of 114 pregnant women attending the antenatal clinics with singleton pregnancies at gestational age between 37 weeks and 41 weeks and 6 days were recruited. Fifty seven subjects with borderline amniotic fluid index making up the exposed group were matched with fifty seven unexposed subjects with normal amniotic fluid index for gestational age, age of the parturient and parity. Maternal outcome measuresincluded induction of labour, spontaneous labour, assisted vaginal delivery, antepartum and intrapartum Caesarean Section. Fetal outcome measures assessed in this study were Apgar score <7 in 5th minute, meconium stained liquor, intrapartum fetal distress, intrapartum fetal death, early neonatal death, birth weight < 2.5kg and admission to neonatal intensive care unit. These outcome measures were analyzed using Statistical Package for the Social Sciences version 22. Statistical tests of significance between the differences in proportions of outcome measures between the exposed and unexposed groups was done using the Chi square with Yates’ correction where appropriate.

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