Background: Sickle cell anaemia (SCA) is a chronic haemolytic condition often requiring frequent blood transfusions. The end result is that some patients with SCA are prone to transfusion induced iron overload. Assessment of iron status especially in the multi- transfused patients may help in ascertaining some of the complications of SCA arising from chronic transfusion. Aim: This study was aimed at assessing serum iron, serum ferritin, total iron binding capacity and percentage transferrin saturation and liver function tests. How the iron parameters relate with the number of unit of blood transfused. Subject and method: The study population includes a total of eighty-six subjects comprising of sixty adult sickle cell anaemia patients and twenty-six healthy HbAA control subjects. The sickle cell anaemia subjects were further divided into 2 subgroups on the basis of the number of units of blood transfused. Full blood counts were measured by automated cell counter. The liver function tests were assayed by a spectrophotometer. The serum ferritin concentration was assayed using ELISA method. Serum iron and total iron binding capacity were assayed using a spectrophotometer and percentage transferrin saturation was determined by calculating the ratio of serum iron to total iron binding capacity expressed in percentage. Results were analysed using statistical package for social science (SPSS) version 16; student t-test was used to compare means and pearson’s correlation coefficient for associations between variables. Probability values of less than or equal to 0.05 was taken as significant.