Background: Immunohistochemistry is an important investigative tool used in making diagnosis of Small Round Blue Cell Tumours. These immunostains when used as a routine technique in correlation with clinical site of tumours and morphology will permit accurate and specific diagnosis of these undifferentiated tumours to be made. The aim of this study is to carry out a ten-year retrospective analysis of the histopathological and immunohistochemical features of small round blue cell tumours in OAUTHC. Method: We retrospectively reviewed our data of histological results over the last ten years and retrieved all the diagnosed cases of small round blue cell tumours over this period. The haematoxylin and eosin stained slides were reviewed to make the diagnosis and different immunohistochemical stains were done on these tumours depending on the morphology and clinical site of the tumour to confirm the histological sub-types.