Breast carcinoma is a disease of utmost concern to the individual, family and society at large. The current trend in the management of breast carcinoma involves hormonal therapy. Consequently the hormone expression of the tumour in the individual involved must be known if he or she is to benefit from such therapy. It is important to note that no work has been done on this in my centre. This is a study of oestrogen and progesterone receptors as well as Her-2/neu expression of breast carcinomas seen at the Lagos State University Teaching Hospital, Ikeja over a five-year period (1st July, 2007 – 30th June, 2012). The total number of cases analysed during the period under study was 458 and they were all females with an age range of 23 to 85 years, a mean age of 48 ± 12.03 years and a median age of 46 years. Tumour size ranged from 0.4cm to 21.5cm. Invasive ductal carcinoma accounted for 91.5% of the histological types. The tumours fell into histological grade I (10.5%), grade II (48.5%) and grade III (41.0%). They expressed ER, PR and Her- 2/neu positivity in 6.8%, 2.2%, and 4.4% of cases respectively. In conclusion, this study shows that breast carcinomas occurred predominantly in females of younger age and present with large tumour size, most of which were of high grade and exhibit triple negativity. Determination of hormone receptor and Her-2/neu expression of individual breast carcinoma case is advocated as well as an improvement in breast carcinoma screening programmes so that the disease can be detected early