Background: Breast cancer is the most common cancer in females and the most common cause of cancer death among women worldwide. Oestrogen receptor (ER), Progesterone receptor (PR) and Human Epidermal growth factor receptor Type 2 (Her2/neu) analysis have been accepted as established procedures in the routine management of patients with breast cancer. This study is designed to determine the prevalence of hormonal receptors (Oestrogen and Progesterone) and Her2/neu receptor experssion in breast cancer patients in ABUTH Zaria, as well as to compare tumour grade with hormone and Her2/neu receptor expression. Materials and methodos: This retrospective study was based on histologically confirmed cases of breast cancers diagnosed in Ahmadu Bello University Teaching Hospital Zaria within five years between January, 2009 – December, 2013. Cases were retrieved from the departmental records and reviewed for histological typing using the 2013 WHO classification of breast cancers, and then reviewed for Immunohistochemical staining for ER, PR and Her2/neu, and scored using quick score. Data was analysed using SPSS version 2.0 and results were presented in frequency distribution tables and figures.